Faltering Growth / Failure to Thrive

Growth problems

Faltering growth is defined by the WHO as a fall in weight for age Z-score of ≥ 1.0 that merits evaluation (WHO 2014). The term is used to refer to a slower rate of weight gain in childhood than expected for age and sex (UK NICE guidelines 2017). 

However, in a recent review they propose that a time frame should be added to ensure children are not falsely categorized with growth faltering, especially following an acute illness such as diarrhea or vomiting (Cook R et al 2023). 

As there are many biological, psychosocial and environmental processes that can lead to malnutrition, FTT should never be a diagnosis in itself (Cole et al 2011).

If we consider average growth, then most infants have tripled their birth weight by the first birthday and increased their length by about 24 centimetres (Mayo Clinic, 2023). But all babies are different, and their growth comes in spurts, so it not constant.

Faltering Growth & CMPA

What causes faltering growth/failure to thrive in infants?

Growth problems can be caused by a number of factors both organic (illness) and non-organic (non-illness related), including genetics, hormonal disorders, illnesses, and poor absorption of food (the Boston Children's Hospital, 2023). 

Organic causes include a Cow’s Milk Protein Allergy (CMPA), congenital and metabolic disorders, as well as infections, which result in inadequate nutrient uptakes for the infant to achieve optimal growth (Cole et al 2011; Krugman SC. and Dubowitz H.2003).

Could it be a symptom of Cow’s Milk Protein Allergy?

In cases of severe CMPA in breastfed infants, failure to thrive has been reported, which can have detrimental long-term consequences. Failure to thrive is one of the general symptoms of CMPA and may result as a culmination of several other factors (Koletzko et al 2012; Vandenplas et al 2007).

It is recommended that infants presenting with failure to thrive (and sick infants with hematochezia), require urgent referral and full diagnostic work up.