INFORMATION FOR BOTTLE FED BABIES ONLY. SMA Alfaré® HMO Formula should not be used unless prescribed by your healthcare professional.
Alfaré® HMO Formula
Whey based extensively hydrolyzed, lactose free, nutritionally complete hypoallergenic specialty formula with 2 HMO (2’-FL and LNnT) and Medium Chain Triglycerides (MCT) for effective first-line symptom relief in infants and young children with CMPA-related malabsorption/maldigestion.
- Proven hypoallergenicity with a tolerance of 98.4% in infants with cow’s milk protein allergy (CMPA) (Nowak-Wegryzn A, et al. Nutrients. 2019). Althéra HMO and Alfaré HMO have the highest degree of hydrolysis globally amongst extensively hydrolysed formulas (Nutten, 2021)
- Provides immune enhancing properties, with the addition of 2 HMO (2’-FL and LNnT†) to support the growth of beneficial bacteria and the production of important short chain fatty acids.(Bode L. Glycobiology. 2012;Bode L. Early Hum Dev. 2015)
- Optimal management of gastrointestinal symptoms and growth promotion in infants with gastrointestinal-related disorders (Vandenplas Y, et al. Amino Acids. 2010; Mila PJ, et al. ESPGHAN Congress. 2004). Tailored to facilitate tolerance and absorption with low osmolarity (<200 mOsm/L) and 40% MCT
- 100% whey-based extensively hydrolyzed formula (eHF)
- Contains 40% of fat as MCT
- Lactose free
- Contains 2 HMO - 2’-FL and LNnT†
- Contains DHA and ARA (1:1 ratio)
- Contains nucleotides
- Free from palm oil
†LNnT = Lacto-N-neotetraose; 2’-FL= 2’fucosyllactose; eHF = Extensively hydrolyzed formula; HMO = Human milk oligosaccharids; Docosahexaenoic acid (DHA); Arachidonic acid (ARA).
Preparing Althéra® HMO is very similar to how you prepare standard infant formula. The step-by-step instructions on how to prepare Althéra® HMO are:
STEP 1 Wash hands before preparation.
STEP 2 Wash hands before preparation.
STEP 3 Boil for 5 min. Leave covered until use.
STEP 4 Boil drinking water for 5 min, allow to cool.
STEP 5 Pour exact amount of lukewarm water into bottle.
STEP 6 Pour exact amount of lukewarm water into bottle.
STEP 7 Shake bottle until powder fully dissolved.
STEP 8 Close tin tightly after each use and store in a cool, dry place.
WARNING “Unboiled water, unsterilsed bottles or incorrect dilution can make your baby ill. Incorrect storage, handling, preparation and feeding can also lead to adverse effects. Follow instructions carefully.”
| AGE | QTY PER MEAL (ML) | QTY PER MEAL (SCOOPS) | MEALS PER DAY |
|---|---|---|---|
|
1-2 weeks
|
90
|
3
|
6
|
|
2-4 weeks
|
120
|
4
|
7
|
|
3-4 weeks
|
150
|
5
|
5
|
Ingredients
Maltodextrin (Corn), Enzymatically Hydrolyzed Whey Protein (Milk), Vegetable Oils (Palm Olein, Sunflower, Rapeseed, Blackcurrant Seed), Medium Chain Triglycerides (2.5%), Potato Starch, Minerals (Calcium Glycerophosphate, Magnesium Chloride, Sodium Chloride, Potassium Phosphate, Potassium Chloride, Calcium Phosphate, Ferrous Sulphate, Zinc Sulphate, Copper Sulphate, Potassium Iodide, Manganese Sulphate, Calcium Chloride), Emulsifier (E472c), Vitamins [Sodium Ascorbate (Vit C), Dl-Alpha-Tocopheryl Acetate (Vit E), Niacinamide (Niacin), Calcium Pantothenate, Riboflavin (Vit B2), Retinyl Acetate (Vit A), Pyridoxine Hydrochloride (Vit B6), Thiamine Mononitrate (Vit B1), Folic Acid, Phylloquinone (Vit K1), D-Biotin, Cholecalciferol (Vit D3), Cyanocobalamin (Vit B12)], Fish Oil, Taurine, Choline Bitartrate, Inositol, Nucleotides (Cytidine 5’-Monophosphate, Uridine 5’-Monophosphate, Adenosine 5’-Monophosphate, Guanosine 5’-Monophosphate), L-Carnitine. Contains Fish Oil and Milk.
For infants and young children with CMPA-related malabsorption/maldigestion (gastrointestinal). It is suitable for infants with CMPA with secondary lactose intolerance due to severe diarrhoea. It can be used as a sole source of nutrition from birth to 12 months of age, and as a supplement, in combination with age-appropriate complementary foods for infants from around 6 months of age.
Fictional case study for Althéra® HMO
NAME & AGE
Edward, 9 months old
FEEDING
Exclusively formula-fed
SYMPTOMS
Eczema, diarrhoea, inconsolable crying
DIAGNOSIS
Suspected CMPA
For the majority of infants with CMPA who cannot be breastfed, symptom relief can be achieved by eliminating cow’s milk proteins from the infant’s diet with an extensively hydrolysed formula,21-23 like Althéra® HMO.1-7
However, not all extensively hydrolysed formulas are the same. Althéra® HMO has the smallest peptide size (only 1% peptides above 1200 Daltons), resulting in a lower risk of allergic reactions.5
In an observational trial, an extensively hydrolysed formula with 10% peptides above 1200 Daltons did not achieve adequate allergy symptom control in >50% of infants, requiring amino acid formula reintroduction.5,40
Conversely, in a clinical trial, Althéra® was shown to relieve symptoms in 100% of infants with CMPA and is the only extensively hydrolysed formula to demonstrate similar efficacy and safety as an amino acid formula, which are generally reserved for severe symptoms of CMPA. Infants fed Althéra® also had:1
How it works
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IMPORTANT NOTICE: Mothers should be encouraged to continue breastfeeding even when their infants have CMA. This usually requires qualified dietary counselling to completely exclude all sources of cows’ milk protein from the mothers’ diet. If a decision to use a special formula intended for infants is taken, it is important to give instructions on correct preparation methods, emphasising that unboiled water, unsterilised bottles or incorrect dilution can all lead to illness. Formula for special medical purposes intended for infants must be used under medical supervision
